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Phenotype Images associated with this Allele
Nomenclature
Symbol: Mmp21b2b2458Clo
Name: matrix metallopeptidase 21; Bench to Bassinet Program (B2B/CVDC), mutation 2458 Cecilia Lo
MGI ID: MGI:5554438
Synonyms: c.T973A, Koli, p.Tyr325Asn
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2458-002-LA exhibits heterotaxy with levocardia, right lung isomerism (3R/3L), dextrogastria, and interrupted aortic arch which is confirmed by EFIC imagingMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
EFIC SummaryMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Serial 2D EFIC image stack in the coronal plane of 2458-002-LA shows TGA {A,D,D}, unbalanced AVSD, common atrium, hypoplastic RV, interrupted aortic arch (type B), and right lung isomerism
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-LA shows immotile cilia
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-LA exhibits heterotaxy with right lung isomerism (3R/3L) and hypoplastic LVMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-LA presents with interrupted and anterior aortic arch which is also seen by EFIC imaging and is diagnosed with TGAMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-NB shows micrognathiaMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-NB presents with a malaligned sternumMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-NB exhibits heterotaxy with dextrocardia, right lung isomerism (3R/4L), dextrogastria, and anterior aorta which is confirmed to be TGA by EFIC imagingMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-NB has dextrocardia with left aortic arch and the aorta anterior, which was diagnosed as TGA by EFIC imagingMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
EFIC SummaryMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Serial 2D EFIC image stack in the coronal plane of 2458-004-NB shows dextrocardia, TGA {A,L,L}, AVSD, left aortic arch, mLV hypertrophy, and right lung isomerism
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-2 (E16.5) is diagnosed with heterotaxy with dextrocardia, dextrogastria, parallel outflow tracts and a thin mRV which is confirmed to be DORV and mRV non-compaction as seen by EFIC imagingMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
EFIC SummaryMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Serial 2D EFIC image stack in the coronal plane of 2458-004-2 (E16.5) shows dextrocardia {A,L,L}, DORV, non-committed VSD, spongy mRV, dual IVC, pulmonary vein connected to RA, and right lung isomerism
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-NC presents with micrognathiaMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-NC exhibits heterotaxy with right lung isomerism (3R/3L)Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-002-NC presents with anterior aorta and malpositioned outflow which is diagnosed as Taussig-Bing type DORV by EFIC imagingMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
EFIC SummaryMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Serial 2D EFIC image stack in the coronal plane of 2458-002-NC shows Taussig-Bing type DORV, AVSD {S,D,D}, and right lung isomerism
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Mutant 2458-004-3 (E16.5) exhibits heterotaxy with levocardia and right lung isomerism (3R/3L)Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
EFIC SummaryMmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Serial 2D EFIC image stack in the coronal plane of 2458-004-3 (E16.5) shows DORV, AVSD, mVSD, and right lung isomerism
Click thumbnail to play movie.		Mmp21b2b2458Clo/Mmp21b2b2458CloC57BL/6J-Mmp21b2b2458Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory