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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah5b2b2395Clo
Name: dynein, axonemal, heavy chain 5; Bench to Bassinet Program (B2B/CVDC), mutation 2395 Cecilia Lo
MGI ID: MGI:5552945
Synonyms: Peaches
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2395-006-LB presents with heterotaxy and dextrocardia with levogastriaDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
EFIC SummaryDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Serial 2D EFIC stack in the coronal plane of 2395-006-LB shows mirror image dextrocardia {I,L,I}, pmVSD, and small mRV
Click thumbnail to play movie.		Dnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-006LB exhibits immotile cilia
Click thumbnail to play movie.		Dnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-006-LA has situs inversus totalisDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-006-LA has immotile cilia
Click thumbnail to play movie.		Dnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-006-LI presents with situs inversus totalis with dextrocardia and dextrogastriaDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-006-LI shows immotile cilia
Click thumbnail to play movie.		Dnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA presents with microphthalmia, short snout, and micrognathiaDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA exhibits a cleft palateDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA has a malaligned sternal vertebraDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA exhibits heterotaxy with dextrocardia, left lung isomerism (1R/1L), and dextrogastriaDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA shows dextrocardia, ventricular hypertrophy, and pulmonary stenosisDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA has a duplex left kidney and cystic kidneyDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
EFIC SummaryDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Serial EFIC image stack of 2395-004-NA in the coronal plane reveals dextrocardia {A, L, L(I)}, AVSD, anomalous coronary venous connected to left SVC, dual IVC, left atrial isomerism, biventricular hypertrophy, and left lung isomerism
Click thumbnail to play movie.		Dnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA has a duplex right kidneyDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Mutant 2395-004-NA has a duplex left kidneyDnah5b2b2395Clo/Dnah5b2b2395CloC57BL/6J-Dnah5b2b2395Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory