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Phenotype Images associated with this Allele
Nomenclature
Symbol: Igs1tm11(CAG-Bgeo,-Edn2)Nat
Name: intergenic site 1; targeted mutation 11, Jeremy Nathans
MGI ID: MGI:5544083
Synonyms: Z/Edn2
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Retinal vascular defects in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 miceIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Inhibition of vascular growth and production of excess tip cells in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 retinasIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
In developing Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 retinas, large regions of the endothelial cell network are not perfusedIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Altered vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 retinasIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Interstitial tip cells in adult Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pdgfra-cre)1Clc/0 retinasIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pdgfra-cre)1Clc/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pax6-cre,GFP)2Pgr/0 miceIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Inhibition of vascular development and midgestational lethality in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 embryosIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Edil3Tg(Sox2-cre)1Amc/Edil3+		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Increased filopodia density in the interior of the Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 retinal vascular plexus at P7Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Absence of vascular defects in the skin of adult Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(KRT5-cre)5132Jlj/0 miceIgs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(KRT5-cre)5132Jlj/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J
Absence of vascular defects in the brains of embryonic day 18 Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Foxg1tm1(cre)Skm/Foxg1+Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Foxg1tm1(cre)Skm/Foxg1+		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory