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Phenotype Images associated with this Allele
Nomenclature
Symbol: Robo1b2b872Clo
Name: roundabout guidance receptor 1; Bench to Bassinet Program (B2B/CVDC) mutation 872, Cecilia Lo
MGI ID: MGI:5496051
Synonyms: c.T809C, Mulan Rocket, p.I270T, Robo1I270T
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 872-004-LA exhibits dilated atria, with biventricular hypertrophy noted by histopathologyRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
EFIC SummaryRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Serial 2D EFIC image stack in the coronal plane of 872-004-LA shows biventricular hypertrophy, dilated atria and systemic venous return
Click thumbnail to play movie.		Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-LA exhibits multiplex kidneys and abnormal gonad developmentRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-LA exhibits multiplex/dysplastic/cystic kidneysRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-LA shows bilateral duplex kidneys with cystic kidney diseaseRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-LA has cystic collecting ducts (green) with knobby cilia (red) varying in lengths from very short to very long; some have been detached into the lumenRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-LA has cystic collecting ducts (green) with knobby cilia (red) of varying lengthsRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 873-004-NC exhibits double outlet right ventricle (DORV)Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
EFIC SummaryRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Serial 2D EFIC image stack in the coronal plane of 872-004-NC reveals DORV {S,D,D}, subaortic VSD, and muscular VSD
Click thumbnail to play movie.		Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE exhibits facial cleft with protruding tongueRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE exhibits dilated atria, with perimembranous VSD and biventricular hypertrophy noted by histopathologyRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE presents with duplex kidneysRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE has duplex and cystic kidneysRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
EFIC SummaryRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Serial 2D micro-MRI image stack in the coronal plane of 872-004-NE reveals perimembranous VSD, bilateral duplicated kidney
Click thumbnail to play movie.		Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE has multi-kidneys fused together and contains many cystsRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Serial 2D EFIC image stack in the coronal plane of 872-004-NE shows small pmVSD, biventricular hypertrophy, dilated atria, and systemic venous return
Click thumbnail to play movie.		Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE has cystic collecting ducts (green) with knobby cilia (red); some have been detached into the lumenRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE has cystic ureteric buds (green) and tubules in general, with knobby cilia (red) of varying lengthsRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NE has knobby cilia (red) of varying lengths in collecting ducts (green)Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has cleft palateRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has dilated atriaRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has multiplex and cystic kidneysRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has multiplex cystic kidneysRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Serial 2D micro-MRI image stack in the coronal plane of 872-004-NA reveals cleft palate, bilateral duplex/multiplex kidney, and hydronephrosis
Click thumbnail to play movie.		Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA kidneys are hydronephrotic and cysticRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has multiplex kidneys, with each lobe comprising a partially formed kidney. The kidneys show hydronephrotic and are cystic.Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA kidneys are hydronephrotic and cystic.Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has long cilia (red) in ureteric buds (green). DAPI labeling of nuclei (blue)Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 872-004-NA has long cilia (red) in non-cystic collecting ducts (green). DAPI (blue) staining of nucleiRobo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Mutant 874-004-NA has long cilia (red) in the cystic collecting ducts (DBA, green). Nuclei are stained with DAPI (blue).Robo1b2b872Clo/Robo1b2b872CloC57BL/6J-Robo1b2b872Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory