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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2350Clo
Name: Mutant line 2350; Bench to Bassinet Program (B2B/CVDC), mutation 2350 Cecilia Lo
MGI ID: MGI:5491275
Synonyms: Hugdos
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2350-007-8 (E13.5) exhibits situs inversus totalis with dextrocardia and inverted outflowb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
EFIC Summaryb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of 2350-007-8 (E15.5) shows mirror image dextrocardia {I,L,I}
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D micro-CT image stack in the coronal plane of 2350-007-8 (E13.5) reveals situs inversus totalis {I,L,I}
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-8 (E13.5) has situs inversus totalis with dextrogastria and inverted liver lobationb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-2 (E13.5) presents with absent sternal vertebraeb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-2 (E13.5) exhibits heterotaxy with dextrocardia and normal gut situsb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-2 (E13.5) has parallel outflow tracts that indicates DORV (Taussig-Bing type) which is confirmed by EFIC imagingb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
EFIC Summaryb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of 2350-007-2 (E13.5) shows dextrocardia {A,L,L}, Taussig Bing type DORV, AVSD, left hepatic vein connecting to atrium, and aberrant left subclavian artery forming incomplete vascular ring
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-1 (E13.5) was dead in utero and exhibited absent sternum vertebrae with abnormal heartb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-1 (E13.5) has heterotaxy, dextrocardia with RAA and primitive heart with superior-inferior ventriclesb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of dead fetus, 2350-007-1 (E15.5) shows developmental delay, superior inferior ventricles, DORV, AVSD, double aortic arch, and ventricular non-compactionb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-007-6 (E13.5) may have an overriding aortab2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
EFIC Summaryb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of 2350-007-6 (E13.5) reveals overriding aorta and pmVSD
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-004-1 (E15.5) has dextroversionb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2035-004-1 (E15.5) exhibits heterotaxy with dextrogastriab2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
EFIC Summaryb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of 2350-004-1 (E15.5) shows dextroversion, DORV, AVSD {S,D,D}, and bilateral single lung lobe
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Color flow spectral Doppler imaging in the sagittal view of mutant 2350-004-1 (E15.5) shows the two great arteries predominantly originating from the RV, which suggests DORV
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
The 2D echo image of 2350-004-1 (E15.5) in frontal view shows right-sided stomach and dextroversionb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-004-1 has tubular dilations and some glomerular cystsb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-006-2 (E15.5) exhibits heterotaxy with anterior positioning of the aorta, non-compaction, and dextrogastriab2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Mutant 2350-006-2 (E15.5) exhibits heterotaxy with RAA and dextrogastriab2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
EFIC Summaryb2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Serial 2D EFIC image stack in the coronal plane of 2350-006-2 (E15.5) reveals AVSD {A,D,D}, common atrium, RAA, RV non-compaction, malrotation of the great arteries, and left lung isomerism
Click thumbnail to play movie.		b2b2350Clo/b2b2350CloC57BL/6J-b2b2350Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory