Phenotype Images associated with this Allele

Nomenclature

Symbol:	Ndst1^b2b2230Clo
Name:	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Bench to Bassinet Program (B2B/CVDC), mutation 2230 Cecilia Lo
MGI ID:	MGI:5491260
Synonyms:	Otto

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2230-003-1 (E16.5) exhibits mesocardia and hypoplastic thymus	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	EFIC Summary	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Serial 2D EFIC image stack in the coronal plane of 2230-003-1 (E16.5) shows mesocardia, PTA (Type A4), AVSD, ventricular hypertrophy, and incomplete vascular ring Click thumbnail to play movie.	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-1 (E16.5) exhibits anophthalmia, anencephaly, agnathia, and low-set ears	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-1 (E16.5) exhibits hydronephrosis, hydroureter, and cystic	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-1 has a hydronephrotic left kidney with hydroureter and tubule cysts; the right kidney has dilatations and less pronounced cysts	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-ND presents with abnormal outflow tract and aortic arch vessels, shown to comprise of PTA with IAA and incomplete vascular ring by histpathology	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	EFIC Summary	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Serial 2D EFIC image stack in the coronal plane of 2230-003-ND shows PTA (Type A4), interrupted aortic arch (IAA), incomplete vascular ring, and biventricular hypertrophy Click thumbnail to play movie.	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-1 (E16.5) shows abnormal, dysplastic kidneys, and a long right kidney	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-ND presents with anopthalmia, and agnathia associated with a proboscis, low-set ears, and microstomia (otocephaly)	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-003-ND presents with Mutant 2230-003-ND presents with anopthalmia (possible cyclopia), and agnathia associated with a proboscis, low-set ears, and microstomia (otocephaly)	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-005-1 (E16.5) exhibits right aortic arch (RAA) and abnormal outflow tract septation suggestive of persistent truncus arteriosus (PTA), which was confirmed by EFIC imaging	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	EFIC Summary	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Serial 2D EFIC image stack in the coronal plane of 2230-005-1 (E15.5) shows PTA (Type A1), RAA, and thick LV Click thumbnail to play movie.	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-005-1 (E16.5) presents with hydronephrosis, possibly cystic kidneys, abnormal gonad development, and malpositioning of the bladder	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-005-1 (E16.5) presents with an omphalocele	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo
	Mutant 2230-005-1 (E16.5) exhibits a short snout, anophthalmia, omphalocele, and growth restriction	Ndst1^b2b2230Clo/Ndst1^b2b2230Clo	C57BL/6J-Ndst1^b2b2230Clo

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