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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ndst1b2b2230Clo
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Bench to Bassinet Program (B2B/CVDC), mutation 2230 Cecilia Lo
MGI ID: MGI:5491260
Synonyms: Otto
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2230-003-1 (E16.5) exhibits mesocardia and hypoplastic thymusNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
EFIC SummaryNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Serial 2D EFIC image stack in the coronal plane of 2230-003-1 (E16.5) shows mesocardia, PTA (Type A4), AVSD, ventricular hypertrophy, and incomplete vascular ring
Click thumbnail to play movie.
Ndst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-1 (E16.5) exhibits anophthalmia, anencephaly, agnathia, and low-set earsNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-1 (E16.5) exhibits hydronephrosis, hydroureter, and cysticNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-1 has a hydronephrotic left kidney with hydroureter and tubule cysts; the right kidney has dilatations and less pronounced cystsNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-ND presents with abnormal outflow tract and aortic arch vessels, shown to comprise of PTA with IAA and incomplete vascular ring by histpathologyNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
EFIC SummaryNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Serial 2D EFIC image stack in the coronal plane of 2230-003-ND shows PTA (Type A4), interrupted aortic arch (IAA), incomplete vascular ring, and biventricular hypertrophy
Click thumbnail to play movie.
Ndst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-1 (E16.5) shows abnormal, dysplastic kidneys, and a long right kidneyNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-ND presents with anopthalmia, and agnathia associated with a proboscis, low-set ears, and microstomia (otocephaly)Ndst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-003-ND presents with Mutant 2230-003-ND presents with anopthalmia (possible cyclopia), and agnathia associated with a proboscis, low-set ears, and microstomia (otocephaly)Ndst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-005-1 (E16.5) exhibits right aortic arch (RAA) and abnormal outflow tract septation suggestive of persistent truncus arteriosus (PTA), which was confirmed by EFIC imagingNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
EFIC SummaryNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Serial 2D EFIC image stack in the coronal plane of 2230-005-1 (E15.5) shows PTA (Type A1), RAA, and thick LV
Click thumbnail to play movie.
Ndst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-005-1 (E16.5) presents with hydronephrosis, possibly cystic kidneys, abnormal gonad development, and malpositioning of the bladderNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-005-1 (E16.5) presents with an omphaloceleNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo
Mutant 2230-005-1 (E16.5) exhibits a short snout, anophthalmia, omphalocele, and growth restrictionNdst1b2b2230Clo/Ndst1b2b2230CloC57BL/6J-Ndst1b2b2230Clo

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory