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Phenotype Images associated with this Allele
Nomenclature
Symbol: Adamts6b2b2228Clo
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2228 Cecilia Lo
MGI ID: MGI:5491258
Synonyms: Willy
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2228-006-2 (E16.5) exhibits malalignment of the great arteries with a hypoplastic aortaAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
EFIC SummaryAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2228-006-2 (E16.5) has DORV, AVSD, and hypoplastic aorta
Click thumbnail to play movie.		Adamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-006-2 (E16.5) exhibits abnormal flexure of the hindlimbs and a short snoutAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-006-2 (E16.5) has hypoplastic thymusAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-004-1 (E14.5) presents with a short snout, abnormal flexure of the hindlimbs, and hydropsAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-004-1 (E14.5) exhibits a cleft palateAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-004-1 (E14.5) exhibits a hypoplastic thymusAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Mutant 2228-004-1 (E14.5) has a slightly abnormal arrangement of the great arteries; the pulmonary is further to the left, confirmed to be DORV by EFIC imagingAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
EFIC SummaryAdamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Serial 2D EFIC image stack in of 2228-004-1 (E14.5) in the the coronal plane shows DORV and subaortic VSD
Click thumbnail to play movie.		Adamts6b2b2228Clo/Adamts6b2b2228CloC57BL/6J-Adamts6b2b2228Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory