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Phenotype Images associated with this Allele
Nomenclature
Symbol: Adamts6b2b2029Clo
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2029 Cecilia Lo
MGI ID: MGI:5487287
Synonyms: Peep
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2029-003-NC exhibits a dilated right ventricle (RV), malaligned great arteries, which is confirmed as double outlet right ventricle by EFIC imaging. The pulmonary artery is dilated, while the ascending aorta is hypoplastic.Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
EFIC SummaryAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Serial 2D EFIC image stack of 2029-003-NC in the coronal plane reveals double outlet right ventricle (DORV), subaortic VSD, hypoplastic aorta, thick semilunar valves and biventricular hypertrophy
Click thumbnail to play movie.		Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NC has craniofacial defects comprising of short snout, micrognathia, and dome-shaped head as well as hindlimb anomalies.Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NC presents with a cleft palateAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NC shows an unfused sternumAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NC exhibits a hypoplastic thymusAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NB has craniofacial defects comprising of short snout, micrognathia, and a dome shaped head. This is accompanied by abnormally attached hindlimbs.Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-NB has a dilated pulmonary artery (PA) and malaligned great arteries indicating overriding aorta, which was confirmed by EFIC imaging.Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
EFIC SummaryAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Serial 2D EFIC image stack of 2029-003-NB in the coronal view exhibits overriding aorta, perimembranous VSD, dilated pulmonary artery (PA), thick semilunar valves and biventricular hypertrophy
Click thumbnail to play movie.		Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-2 (E16.5) has a dome-shaped head, micrognathia, and abnormally attached hindlimbsAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-2 (16.5) presents with an unfused sternumAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Mutant 2029-003-2 (E16.5) is exhibits parallel outflow tracts, indicating DORV, which is confirmed by EFIC imagingAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
EFIC SummaryAdamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2029-003-2 (E16.5) shows DORV, AVSD, and biventricular hypertrophy
Click thumbnail to play movie.		Adamts6b2b2029Clo/Adamts6b2b2029CloC57BL/6J-Adamts6b2b2029Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory