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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b1801Clo
Name: Mutant line 1801; Bench to Bassinet Program (B2B/CVDC), mutation 1801 Cecilia Lo
MGI ID: MGI:5446159
Synonyms: Buzz
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1801-002-NA exhibits dextrocardia and dextrogastria with inverted liver lobation.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-002-NA exhibits abnormal right hemizygous venous connection.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial micro-MRI image stack of 1801-002-NA in the coronal plane reveals heterotaxy, dextrocardia, right hemiazygous venous connection with left-side hepatic vein connects to left-side atrium, dextrogastria and inverted liver
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial 2D EFIC image stack of 1801-002-NA in the coronal plane reveals dextrocardia {I,L,L}, right hemiazygous venous connection, left ventricular hypertrophy
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-003-NC exhibits dextrocardia with transposition of the great arteries (TGA) and right pulmonary isomerism.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-003-NC has dextrocardia with transposition of the great arteries (TGA), right pulmonary isomerism, inverted liver lobation, and dextrogastria.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial 2D EFIC image stack of 1801-003-NC in the coronal plane reveals dextrocardia, transposition of the great arteries {I,L,L}, and abnormal lung lobation
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-003-LA exhibits right lung isomerism (4R/3L) and duplicated inferior vena cava (IVC).b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-003-LA exhibits anterior positioning of the aorta indicating transposition of the great arteries (TGA), duplicated inferior vena cava (IVC), and right pulmonary isomerism.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-003-LA shows dextrogastriab2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial 2D EFIC image stack of 1801-003-LA in the coronal plane reveals heterotaxy, transposition of the great arteries {S,D,D}, atrioventricular septal defect (AVSD), duplicated inferior vena cava (IVC), and right lung isomerism
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-005-LC exhibits heterotaxy with dextrocardia, transposition of the great arteries (TGA) with aorta positioned anteriorly, and right pulmonary isomerism with four lung lobes bilaterallyb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial 2D EFIC image stack of 1801-005-LC in the coronal plane reveals dextrocardia, TGA {I,L,L}, VSD, hypoplastic PA
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-005-LB exhibits heterotaxy with dextrocardia and inverted lung lobation.b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Serial 2D EFIC image stack of 1801-005-LB in the coronal plane reveals dextrocardia, double outlet right ventricle (DORV) {I,L,L} with subaortic VSD
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
Anks6b2b1801.1Clo/Anks6b2b1801.1CloC57BL/6J-Anks6b2b1801.1Clo
Mutant 1801-004-LC shows a slightly stenotic transverse arch and the pulmonary artery is positioned further posterior which confirms the micro-CT finding of double outlet right ventricle (DORV)b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
Serial 2D EFIC image stack of 1801-004-LC in the coronal plane reveals DORV, subaortic VSD
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
Mutant 1801-004-LA displays a hypoplastic transverse archb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
Mutant 1801-004-LA exhibits a short gutb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
Serial 2D EFIC image stack of 1801-004-LA in the coronal plane reveals DORV, subaortic VSD, muscular VSD {S,D,D}
Click thumbnail to play movie.		b2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
EFIC Summaryb2b1801Clo/b2b1801CloC57BL/6J-b2b1801Clo
b2b1801.2Clo/b2b1801.2CloC57BL/6J-b2b1801.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory