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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnaaf3b2b1739Clo
Name: dynein, axonemal assembly factor 3; Bench to Bassinet Program (B2B/CVDC), mutation 1739 Cecilia Lo
MGI ID: MGI:5442117
Synonyms: Barker
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
EFIC summaryDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Serial 2D EFIC image stack in the coronal plane of 1739-002-MLA reveals mirror image dextrocardia
Click thumbnail to play movie.		Dnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-002-MLA shows heterotaxy with dextrocardia, inverted outflow, left-sided IVC, and inverted lung lobationDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-002-MLA exhibits dextrogastria, left-sided pancreas, and spleen. Spleen is also hypoplasticDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-002-MLA exhibits a malaligned sternumDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-002-MLA has immotile airway cilia
Click thumbnail to play movie.		Dnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-003-LA exhibits situs inversus totalis with dextrocardia and inverted lung lobationDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-003-LA exhibits dextrogastria with normal spleenDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-003-LA exhibits inverted kidney positioning, with left higher than right kidneyDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-003-LA exhibits immotile cilia in the airway epithelia
Click thumbnail to play movie.		Dnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-005-LA exhibit levocardia with left bronchial isomerismDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
EFIC SummaryDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Serial 2D EFIC image stack of 1739-005-LA in the coronal plane reveals duplicated IVC and left bronchial isomerism
Click thumbnail to play movie.		Dnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-005-LA shows malalignment of the sternovertebraeDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Mutant 1739-005-LA presents with dextrogastria and a hypoplastic spleenDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
EFIC SummaryDnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Serial 2D EFIC image stack of 1739-005-NA in the coronal plane reveals hemiazygous venous connection to left SVC
Click thumbnail to play movie.		Dnaaf3b2b1739Clo/Dnaaf3b2b1739CloC57BL/6J-Dnaaf3b2b1739Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory