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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah11b2b1289Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1289, Cecilia Lo
MGI ID: MGI:5437083
Synonyms: Dnahc11c.A5632G, Ghost
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1289-003-NA shows levocardia, right aortic arch and ambiguous lung lobationDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
EFIC SummaryDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Serial 2D EFIC image stack in the coronal plane of 1289-003-NA reveals right aortic arch, mVSDs, biventricular hypertrophy and isolated left subclavian artery forming vascular sling
Click thumbnail to play movie.		Dnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-003-LA exhibits heterotaxy with levocardia, dextrogastria, midline liver, and polyspleniaDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-003-LA reveals levocardia with left lung isomerismDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-003-LA exhibits polysplenia with right sided stomachDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-003-LA reveals malaligned sternal vertebraeDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Videomicroscopy of 1289-003-LA mutant airway reveals motile airway cilia
Click thumbnail to play movie.		Dnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Immunofluorescence of ureteric budDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-019-LC presents with microphthalmia of the left eyeDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-019-LC presents with anophthalmia of the right eyeDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-019-LC exhibits a hypoplastic spleenDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Mutant 1289-019-LC presents with a duplex right kidney that also exhibits hydronephrosis and cysts which is confirmed by histologyDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Right kidney of mutant 1289-019-LC is duplex with likely hydronephrosis and hydroureter. It is also cystic dysplasticDnah11b2b1289Clo/Dnah11b2b1289CloC57BL/6J-Dnah11b2b1289Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory