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Phenotype Images associated with this Allele
Nomenclature
Symbol: Psme4b2b1508Clo
Name: proteasome (prosome, macropain) activator subunit 4; Bench to Bassinet Program (B2B/CVDC), mutation 1508 Cecilia Lo
MGI ID: MGI:5437081
Synonyms: Oscar
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1508-006-LA displays heterotaxy, as indicated by levocardia, anterior positioning of the aorta, right pulmonary isomerism, right sided stomach, and abnormal liver lobationPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-006-LA shows TGA with levocardia, interrupted aortic arch, midline IVC and right pulmonary isomerismPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-006-LA shows levocardia with right pulmonary isomerism and thymus hypoplasia.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-006-LA shows malalignment of the sternovertebraePsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-006-LA shows abnormal positioning with both kidneys at the same axial levelPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
EFIC SummaryPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Serial 2D EFIC image stack in the coronal plane of 1508-006-LA reveals Tricuspid atresia {ALL}, VSD, L-TGA, large ASD, interrupted left aortic arch, and left-sided IVC entering middle portion of atrium, right isomerism lung
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Serial 2D EFIC image stack in the transverse plane of mutant 1508-006-LA reveals tricuspid atresia {ALL}, VSD, and L-TGA
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1508-006-LA reveals tricuspid atresia {A,L,L}, VSD, L-TGA, large ASD, interrupted left aortic arch, and left-sided IVC entering middle of atrium
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-006-LA displays motile airway cilia
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-007-NB displays heterotaxy indicated by dextrocardia, left sided aortic arch (confirmed by EFIC imaging), left sided IVC, and abnormal lung and liver lobationPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-007-NB shows dextrocardia with abnormal ventricles.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-007-NB shows right sided stomach with inverted liver lobation.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
EFIC SummaryPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1508-007-NB reveals dextrocardia {A,L,L}, Taussig-Bing DORV (subpulmonary VSD), AVSD, common atrium, left aortic arch, and right pulmonary isomerism
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
1508-003-NB exhibits mesocardia with anterior aorta, right sided aortic arch (RAA), duplicated inferior vena cava (IVC), malrotated gut and midline liverPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-003-NB displays mesocardia, dual IVC and TGA.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-003-NB exhibits unusually long kidneysPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
EFIC SummaryPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Serial 2D EFIC image stack in the coronal plane of 1508-003-NB reveals heterotaxy with TGA {A,L,L}, tricuspid atresia, VSD, TGA, bilateral IVC, right aortic arch, and right isomerism lung
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-005-MND exhibits levocardia with midline liver.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-005-MND exhibits left pulmonary isomerism and thymus hypoplasiaPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-005-MNB exhibits levocardia with right sided aortic arch, and aortic and pulmonary stenosis and aortic arch hypoplasiaPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Mutant 1508-005-MND exhibits dextrogastria with right sided spleen and pancreas.Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
EFIC SummaryPsme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
2D EFIC image stack in coronal view of animal 1508-005-MND reveals l-TGA, AVSD {S,D,L}, right aortic arch, right isomerism lung
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
2D micro-MRI image stack in the coronal plane of mutant 1508-005-MND reveals tricuspid atresia {S,D,D}, VSD, right aortic arch, right pulmonary isomerism, dextrogastria, and intestinal malrotation.
Click thumbnail to play movie.		Psme4b2b1508Clo/Psme4b2b1508CloC57BL/6J-Psme4b2b1508Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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