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Phenotype Images associated with this Allele
Nomenclature
Symbol: Nek8b2b1449Clo
Name: NIMA (never in mitosis gene a)-related expressed kinase 8; Bench to Bassinet Program (B2B/CVDC), mutation 1449 Cecilia Lo
MGI ID: MGI:5317588
Synonyms: Nek8Roc, Roc
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Heterotaxy indicated by levocardia, dual IVC and dextrogastriaNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Hypoplastic thymuses and duplicated inferior vena cavaNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Duplicated inferior vena cavaNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
EFIC SummaryNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
2D serial EFIC image stacks in the coronal view of mutant 1449-007-LA reveals muscular VSD {ADD} , bilateral IVC, hypoplastic right ventricle and left pulmonary isomerism
Click thumbnail to play movie.		Nek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Mutant 1449-007-LA kidneys show hydronephrosis and hydroureterNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Normal tracheal airway cilia motility
Click thumbnail to play movie.		Nek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Mutant 1440-002-LA kidneys show hydronephrosis, hydroureter, and glomerular cystsNek8b2b1449Clo/Nek8b2b1449CloC57BL/6J-Nek8b2b1449Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory