Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Pcsk5^b2b585Clo
Name:	proprotein convertase subtilisin/kexin type 5; Bench to Bassinet Program (B2B/CVDC), mutation 585 Cecilia Lo
MGI ID:	MGI:5313702
Synonyms:	McRib

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 585-004-1 shows right hindlimb syndactyly.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Mutants show hydrops, no tail and hindlimb syndactyly.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Kidney agenesis in mutant 585-004-1	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
		Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	2D serial EFIC image stack of mutant 585-004-1 in the coronal view reveals PTA (type I), AVSD, double aortic arch (AA), and vascular ring Click thumbnail to play movie.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Mutant 585-004-1 shows kidney agenesis	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	EFIC Summary	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Mutant line 585 reveals mesocardia or dextrocardia with double aortic arch (AA).	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Mutant 585-025-NA show mesocardia with hypoplastic/dysplastic kidneys, supernumerary/malformed ribs, and cleft palate.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	2D serial EFIC image stack in the coronal view of 585-011-2 shows mesocardia with double outlet right ventricle (DORV) and atrioventricular septal defect (AVSD) Click thumbnail to play movie.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo
	Mutant 585-025-NB show dextrocardia, dysplastic kidneys, syndactyly, malpositioned thymus, and malformed ribs.	Pcsk5^b2b585Clo/Pcsk5^b2b585Clo	C57BL/6J-Pcsk5^b2b585Clo

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