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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah11b2b1203Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1203, Cecilia Lo
MGI ID: MGI:5311388
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1203-005-LA exhibits heterotaxy with dextrocardia, inverted lung lobation, inverted liver lobation, and left-sided stomachDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
EFIC summaryDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
2D Serial EFIC image stack in the coronal plane of 1203-005-LA reveals mirror image dextrocardia {A,L,I}, RV lumen smaller than LV lumen
Click thumbnail to play movie.		Dnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Mutant 1203-005-LA shows mostly immotile tracheal airway cilia with some dyskinetic and hyperkinetic motion
Click thumbnail to play movie.		Dnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Mutant 1203-004-LA exhibits situs inversus totalis with dextrocardia, inverted lung lobation, and inverted outflowDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Mutant 1203-004-LA exhibit situs inversus totalis including dextrocardia, inverted lung lobation, inverted liver lobation, and dextrogastriaDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
EFIC summaryDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
2D Serial EFIC image stack in the coronal plane of 1203-004-LA reveals mirror image dextrocardia {I,L,I}, and non-compaction of ventricular myocardium
Click thumbnail to play movie.		Dnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Mutant 1203-004-LA exhibits duplex and cystic kidneysDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Mutant 1203-004-LA exhibits bilateral hydrnephrosis and likely duplex kidneyDnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Immunofluorescence of ureteric bud (green) show short cilia (red) in mutant 1203-004-LADnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Immunofluorescence of collecting duct (green) show paucity of cilia (red) in mutant 1203-004-LADnah11b2b1203Clo/Dnah11b2b1203CloC57BL/6J-Dnah11b2b1203Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory