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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cc2d2ab2b1035Clo
Name: coiled-coil and C2 domain containing 2A; Bench to Bassinet Program (B2B/CVDC), mutation 1035 Cecilia Lo
MGI ID: MGI:5311382
Synonyms: Blue meanie
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Heterotaxy indicated by left lung isomerism with left sided IVC and TGA (observed by EFIC imaging)Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cystic kidneys with right kidney duplicatedCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cleft palateCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Mutant fetus at E16.5 with cleft palateCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
2D serial EFIC image stack in the coronal view reveals tricuspid atresia {ADD}, VSD, common atrium, pulmonary stenosis,and total anomalous pulmonary venous return
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
2D serial EFIC image stack in the transverse view reveals tricuspid atresia {ADD}, VSD, common atrium, and pulmonary stenosis
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Kidney displays tubular and glomerular cystsCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cystic kidney tubulesCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Proximal tubule with no ciliaCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cystic proximal tubulesCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cystic collecting ductsCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Mutant fetus (far left) has anopthalmia compared to littermate controls (2 right)Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
2D serial EFIC image stack in the coronal view reveals DORV {S(A),DD} , subpulmonary VSD, muscular VSD, AVSD, pulmonary artery stenosis and dysplastic PA valve
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Ultrasound imaging in the frontal view reveals dextrocardia and left-sided stomach
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Ultrasound imaging in 2D transverse view reveals unbalanced AVSD
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Ultrasound imaging reveals unbalanced AVSDCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Image capture showed DORV with muscular VSDCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
DORV with muscular VSD.
Click thumbnail to play movie.		Cc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Image capture of color Doppler showed unbalanced AVSD with muscular VSDCc2d2ab2b1035Clo/Cc2d2ab2b1035CloC57BL/6J-Cc2d2ab2b1035Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory