About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Col7a1tm1Lbt
Name: collagen, type VII, alpha 1; targeted mutation 1, Leena Bruckner-Tuderman
MGI ID: MGI:3796248
Synonyms: Col7a1flneo, TgH(COL7A1flNeo)288LBT
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Col7a1tm1Lbt/Col7a1tm1Lbt mice develop blisters early after birthCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Reduced collagen VII deposition in Col7a1tm1Lbt/Col7a1tm1Lbt mice results in dermal-epidermal separationCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Col7a1tm1Lbt/Col7a1tm1Lbt mice exhibit growth retardation as a result of malnutritionCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Paw deformities in Col7a1tm1Lbt/Col7a1tm1Lbt mice resemble severe human recessive dystrophic epidermolysis bullosaCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Mitten deformities of the extremities in the Col7a1tm1Lbt/Col7a1tm1Lbt mouse are not primarily caused by bone abnormalitiesCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Dermal-epidermal separation, higher dermis cellularity and reduced elastic fibers in Col7a1tm1Lbt/Col7a1tm1Lbt skinCol7a1tm1Lbt/Col7a1tm1Lbtinvolves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory