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Phenotype Image Detail
Image
Caption a) Hair phenotype of mice expressing the knock-in construct. Heterozygous mice carrying one wild-type and one knock-in Ctsltm1.2Thre allele (CtslKiTTCdeltaSTOP/wt) show no aberrations in normal coat. Photo of littermates taken at P30 shows Ctsltm1.2Thre/Ctsltm1.2Thre (CtslKiTTCdeltaSTOP/CtslKiTTCdeltaSTOP) mice fully resemble the periodical hair loss due to cathepsin L deficiency, while heterozygous mice show no aberrations.
Copyright This image is from Tholen M, Nat Commun 2014;5():4931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:216506
Associated
Alleles
Symbol Name
Ctsltm1.2Thre cathepsin L; targeted mutation 1.1, Thomas Reinheckel
Associated
Genotypes
Allelic Composition Genetic Background
Ctsltm1.2Thre/Ctsltm1.2Thre involves: C57BL/6 * C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory