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Phenotype Image Detail
Image
Caption Vacuolization and broadened intercellular spaces present in Aldh3a2tm1b(EUCOMM)Wtsi/Aldh3a2tm1b(EUCOMM)Wtsi (-/-) epidermis. A, paraffin sections (4 um) of skin prepared from wild-type (WT) and mutant mice at P0 were subjected to H&E staining. Bright field images were photographed under a DM5000B light microscope. Arrows indicate vacuolization. Bar, 20 um. B and C, skin sections of WT and mutant mice at P0 were subjected to electron microscopy. Arrows indicate broadened intercellular spaces. Bar, 3 um (B), 1 um (C). SC, stratum corneum; SG, stratum granulosum; SS, stratum spinosum; SB, stratum basale; De, dermis.
Copyright This image is from Naganuma T, J Biol Chem 2016 May 27;291(22):11676-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:234695
Associated
Alleles
Symbol Name
Aldh3a2tm1b(EUCOMM)Wtsi aldehyde dehydrogenase family 3, subfamily A2; targeted mutation 1b, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Aldh3a2tm1b(EUCOMM)Wtsi/Aldh3a2tm1b(EUCOMM)Wtsi involves: C57BL * C57BL/6J * C57BL/6N * DBA

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory