About   Help   FAQ
Phenotype Image Detail
Image
Caption Increased sensitivity of heterozygous and homozgyous Aldh2tm1.1Mak mice to damage induced by chronic ethanol challenge. Histology and cleaved caspase 3 staining of mouse liver sections (400x) from wild-type (Aldh2WT), Aldh2tm1.1Mak/Aldh2+ (Aldh2E487K/WT) and Aldh2tm1.1Mak/Aldh2tm1.1Mak (Aldh2E487K/E487K) mice treated with 4g/kg ethanol for 6 weeks.
Copyright This image is from Jin S, Proc Natl Acad Sci U S A 2015 Jul 21;112(29):9088-93. Copyright 2015 National Academy of Sciences, U.S.A. J:223796
Associated
Alleles
Symbol Name
Aldh2tm1.1Mak aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1.1, Tak Mak
Associated
Genotypes
Allelic Composition Genetic Background
Aldh2tm1.1Mak/Aldh2+ involves: 129S6/SvEvTac * C57BL/6J
Aldh2tm1.1Mak/Aldh2tm1.1Mak involves: 129S6/SvEvTac * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory