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Phenotype Image Detail
Image
Caption Increased sensitivity of heterozygous and homozgyous Aldh2tm1.1Mak mice to damage induced by chronic ethanol challenge. Histology and cleaved caspase 3 staining of mouse liver sections (400x) from wild-type (Aldh2WT), Aldh2tm1.1Mak/Aldh2+ (Aldh2E487K/WT) and Aldh2tm1.1Mak/Aldh2tm1.1Mak (Aldh2E487K/E487K) mice treated with 4g/kg ethanol for 6 weeks.
Copyright This image is from Jin S, Proc Natl Acad Sci U S A 2015 Jul 21;112(29):9088-93. Copyright 2015 National Academy of Sciences, U.S.A. J:223796
Associated
Alleles
Symbol Name
Aldh2tm1.1Mak aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1.1, Tak Mak
Associated
Genotypes
Allelic Composition Genetic Background
Aldh2tm1.1Mak/Aldh2+ involves: 129S6/SvEvTac * C57BL/6J
Aldh2tm1.1Mak/Aldh2tm1.1Mak involves: 129S6/SvEvTac * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory