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Phenotype Image Detail
Image
Caption Basement membranes (BM) of adjacent axons in the sciatic nerve are partially fused in Vwa1tm1Jfba/Vwa1tm1Jfba (-/-) mice. Ultrastructural analysis of transverse sections from the sicatic nerve isolated from wild type (WT, +/+) (A, C, and E) and Vwa1tm1Jfba/Vwa1tm1Jfba (B, D, and E), Overviews (A and B) and higher magnifications (C-F) of several axons are shown, and areas of interest are indicated by circles (B). BM of axons in WT mice are separated by an inter-axonal space filled with bundles of collagen I fibrils (ColI). Arrows highlight the alignment of the basement membranes in WT and mutant mice. Bar, 2.8 um (A and B), 460 nm (C-E), 350 nm (F).
Copyright This image is from Allen JM, J Biol Chem 2009 May 1;284(18):12020-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:149746
Associated
Alleles
Symbol Name
Vwa1tm1Jfba von Willebrand factor A domain containing 1; targeted mutation 1, John F Bateman
Associated
Genotypes
Allelic Composition Genetic Background
Vwa1tm1Jfba/Vwa1tm1Jfba C57BL/6-Vwa1tm1Jfba

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory