| Image |
|
||||
| Caption | Histological assessment of liver morphology in fasted and non-fasted wild-type (WT, +/+) and Decr1tm1Jkh/Decr1tm1Jkh (-/-) mice. Light microscopic images of representative paraffin-embedded liver sections from WT and Decr1tm1Jkh/Decr1tm1Jkh mice stained with hematoxylin and eosin (A-D) and cryosections stained with Oil red O (E,F). Liver morphology of non-fasted animals showed no differences between WT and mutant mice (A,B). Fasting for 24 hours revealed no apparent changes in the liver morphology of WT mice, but induced microvesicular steatosis in mutant mice, as observed by the appearance of foamy hepatocytes with centralized nuclei (C,D). Oil red O staining of neutral fat in representative liver cryosections revealed small, lightly stained vacuoles in the WT sample (E), whereas a large number of intensively stained vacuoles of varying size can be seen in mutant mice (F), indicating the accumulation of fat. Magnification X20. | ||||
| Copyright | This image is from Miinalainen IJ, PLoS Genet 2009 Jul;5(7):e1000543, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151622 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools