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| Caption | Characteristic caudal mass/ectopic limb phenotypes in Etn3tm2.1Jwi/Etn3+ offspring. A. (one panel) Bruce4.G9 targeted ES cell clone (9281)-derived chimeric male produced a female heterozygous carrier that was mated to a beta-actin FLPe male to produce the newborn mutant shown in the panel here. Genotyping confirmed the proper FLPe recombination fragment demonstrating Neo cassette removal in this mouse. B., C. Typical caudal masses with ectopic limbs in offspring of mutant mice. 9 out of 69 offspring from mating between mutant males X B6/D2 F1 females demonstrated typical caudal masses/ectopic limbs (3 panels in B), whereas 8 out of 31 offspring from mating between mutant males X FVB females demonstrated typical caudal masses and in one mouse a bifurcated tail seen at birth and later at 3 weeks (5 panels in C). | ||||||
| Copyright | This image is from Lehoczky JA, PLoS Genet 2013 Dec;9(12):e1003967, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:207896 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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