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| Caption | Loss of GLMP (NCU-G1) leads to liver fibrosis and splenomegaly in 6-month-old mice. (A) Representative livers from wild-type (WT) and GlmpGt(P084H04)Wrst/GlmpGt(P084H04)Wrst (Ncu-g1gt/gt) mice. WT liver has a smooth surface with easily recognizable individual lobes, whereas the mutant liver has a fibrotic appearance and a contracted, distorted and nodular appearance. Disruption of Glmp did not result in hepatomegaly, as indicated by the liver weight:body weight ratio (P=0.23, n=6-7). (B) Representative pictures of a WT and mutant spleen. Spleen weight:body weight ratio of WT and mutant spleens shows a significantly enlarged spleen in mutant mice (n=6-7, *P=0.02). | ||||
| Copyright | This image is from Kong XY, Dis Model Mech 2014 Mar;7(3):351-62, and is displayed under the terms of the Creative Commons Attribution-Noncommerical-Share Alike 3.0 Unported License. J:208774 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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