Phenotype Image Detail

Image

Caption

Cross-sectional view of the heart of a wild-type (WT) and Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} (CH Homo) mutant. Note the enlarged right ventricle (RV) in the mutant. Prominent RV enlargement was observed in 6 of 8 Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} mice but no WT controls. (E) Doppler velocity waveform in the proximal pulmonary artery in a WT and CH homozygous deletion mutant. Reversed diastolic blood velocities (arrows) indicate pulmonary valve regurgitation (observed in 8 of 8 CH homozygotes but no WT).

This image is from Kelsey L, PLoS Genet 2013;9(7):e1003612, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206507

Associated
Alleles

Symbol	Name
Klf3^{Gt(CH0516)Wtsi}	Kruppel-like transcription factor 3 (basic); gene trap CH0516, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi}	involves: 129P2/OlaHsd * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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