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Phenotype Image Detail
Image
Caption Reactive gliosis in the cerebellum (Top) and hippocampus (middle) of a Prnptm3Lnq/Prnptm3Lnq (CJD) mouse brain (right) revealed by immunohistochemistry for GFAP. Silver staining of 30-um thick sections from wild-type (WT), Prnptm3Lnq/Prnptm3Lnq (CJD) and Prnptm2Lnq/Prnptm2Lnq (FFI) brains reveals neurodegenerated cells (arrows) and dilated ventricles (arrowhead) in FFI but not CJD brains.
Copyright This image is from Jackson WS, Proc Natl Acad Sci U S A 2013 Sep 3;110(36):14759-64. Copyright 2013 National Academy of Sciences, U.S.A. J:200974
Associated
Alleles
Symbol Name
Prnptm2Lnq prion protein; targeted mutation 2, Susan Lindquist
Prnptm3Lnq prion protein; targeted mutation 3, Susan Lindquist
Associated
Genotypes
Allelic Composition Genetic Background
Prnptm2Lnq/Prnptm2Lnq involves: 129P2/OlaHsd * C57BL/6N
Prnptm3Lnq/Prnptm3Lnq involves: 129P2/OlaHsd * C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory