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| Caption | Diminished insulin stores and mildly disorganized islets in Ero1bGt(P077G11)Wrst/Ero1bGt(P077G11)Wrst (i/i) mutant mice. (A) Hematoxylin- and eosin-stained pancreatic sections of 3-mo-old wild-type (WT) and homozygous mutant mice. (B) Pancreatic insulin content of mice as in A. Shown are the mean and SEM (n = 5; *, P < 0.001 by two-tailed t test). (C) Fluorescent micrographs of frozen section of pancreas from WT (+/+) and homozygous mutant mice (as in A) stained with antisera to insulin (Ins), glucagon, and the karyophilic dye DAPI. The bottom right panel in each genotype is an overlay of the three stains. Note the presence of glucagon-positive cells in the interior of the islet of the mutant. (D) Electron micrographs of insulin-producing Beta cells from islets of Langerhans of WT and mutant mice. Note the lack of ER dilation in the higher magnification views (right) of the mutant sample. Bars: (A and C) 100 um; (D, left) 2 um; (D, right) 0.5 um. | ||||
| Copyright | This image is from Zito E, J Cell Biol 2010 Mar 22;188(6):821-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:158805 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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