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| Caption | Urothelial hyperplasia with increased BrdU incorporation in Cldn4tm1.1Yham/Cldn4tm1.1Yham (Cldn4-/-) mice. (A) Sections of the uretero-pelvic junction regions (left panels) and lower part of the ureters (right panels) of heterozygous and homozygous littermate mice (8-19 month old) with no evidence of hydronephrosis were stained with hematoxylin and eosin. Dotted lines indicate the urothelial basal layers. Note the increased urothelial cell numbers and layers. Bars, 50 um. (B) Heterozygous and homozygous littermate mice (12 months old) were injected with BrdU (1 mg/animal) intraperitoneally for 4 consecutive days, and the sections of the ureters (left) and bladders (right) were three-color immunostained with anti-BrdU (green, arrows), anti-keratin (red), and DAPI (blue). Bars, 50 um. | ||||
| Copyright | This image is from Fujita H, PLoS One 2012;7(12):e52272, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195766 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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