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| Caption | Eyelids open at birth phenotype in Ppp1r13lwoe2/Ppp1r13lwoe2 mice. All mutant neonates were born with bilateral open eyelids (B) to contrast to the wild-type (WT) neonates that have closed eyelids (A). Histological analysis of P0.5 mutant mice confirmed the open eyelid phenotype and also revealed hyperkeratosis of the eyelids, stromal keratitis, absence of the conjunctival sacs, anterior synechiae, and hyperplastic corneas (D) features that were absent in the WT age matched controls (C). Further histological analysis of mutant mice at E18.5 (F) showed failure of the embryonic eyelid closure (arrows) whereas WT controls exhibited embryonic eyelid closure (E). | ||||
| Copyright | This image is from Toonen J, BMC Genet 2012;13():76, an open-access article, licensee BioMed Central Ltd. J:190557 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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