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| Caption | Dumbo ear and cranial malformations. Control (a, c) and Hmx1dmbo/Hmx1dmbo (dumbo; b, d) live mouse images. Note ventrolateral displacement of ear pinnae in the mutant. Image analysis of dissected control and dumbo pinnae revealed no difference in overall surface area, but the mutant ears were less concave, giving the impression of a larger area (data not shown). Most dumbo mice exhibit microphthalmia, as is evident in these images. Lateral (e, f) and dorsal (g, h) views of bone/cartilage skull preps. The calvaria was removed for the dorsal views. Compared to heterozygous controls (e), dumbo skulls (f) show malformations of the squamous temporal bone ("st"; the asterisk marks a region where dumbo mice exhibit an extra notch). Hyperplasia of the gonial bone ("gn") is evident in mutants (f, h) vs controls (e, g). rtp = retrotympanic process; MC = Meckel's cartilage; ma = malleus; tmp = ectotympanic. | ||||
| Copyright | This image is from Monroe RJ, BMC Dev Biol 2009;9(1):27, an open-access article, licensee BioMed Central Ltd. J:147782 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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