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| Caption | A, quantification of slit lamp examination of control (WT) and Selenoftm1Vgla/Selenoftm1Vgla (Sep15 KO) mice. Opacity was quantified using the Lens Opacities Classification System, version II. The scale was from a completely clear (grade 0) to a fully opaque (grade 5) lens. L, left; R, right. B, representative images of opacities in mutant mice using a fundus camera. Six-month-old wild-type (WT) and mutant females were used. L, left; R, right. C-H, representative cataracts in mutant mice. Each panel shows lenses from the same animal. The left panels represent in vivo slit lamp examination, and the right panels show dark field analyses of the same lens examined in vitro. C and D, representative lenses from 2-month-old mutant females. Nuclear opacity is shown with a red arrow. E, 2-month-old WT female (control) showing no nuclear opacity. F and G, 10-month-old mutant females. Nuclear opacity is shown with red arrows. H, 10-month-old WT female that developed age-related punctate opacity. | ||||
| Copyright | This image is from Kasaikina MV, J Biol Chem 2011 Sep 23;286(38):33203-12 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176744 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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