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Phenotype Image Detail
Image
Caption (A) Edema is apparent in the E14.5 Nfat5tm1Skc/Nfat5tm1Skc (NFAT5-/-) embryos (b) compared with a wild-type (NFAT+/+) littermate (a). The arrow indicates the outer skin layer. (B) Histological comparison of wild-type (a and c) and mutant (b and d) embryonic heart at 14.5 days. (C) Representative photomicrograph showing proliferating cell nuclear antigen (PCNA)-positive cells (arrows) in compact zone and trabecular region in E14.5 wild-type and mutant hearts. (D) Representative photomicrography showing the (a and b) Bcl-2, (c and d) Bax and (e and f) cleaved caspase-3 staining (arrows) on E14.4 wild-type and mutant hearts. Com, compact layer; E, endocardial cushion; Endo, endocardium; Ep, epicardium; LV, left ventricle; Tr, trabecular. n = 5 Scale bar = 50 um.
Copyright This image is from Mak MC, PLoS One 2011;6(7):e19186, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:175527
Associated
Alleles
Symbol Name
Nfat5tm1Skc nuclear factor of activated T cells 5; targeted mutation 1, Sookja K Chung
Associated
Genotypes
Allelic Composition Genetic Background
Nfat5tm1Skc/Nfat5tm1Skc involves: 129S7/SvEvBrd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory