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Phenotype Image Detail
Image
Caption (N-P) Terttm1Leah/Terttm1Leah (TERT) knockout prevents telomere elongation in Pinx1tm1.1Kplu/Pinx1+ MEFs at late passage, as determined by qFISH. (P) Terttm1Leah/Terttm1Leah knockout prevents anaphase brides and/or lagging chromosomes in Pinx1tm1.1Kplu/Pinx1+ MEFs at late passage.
Copyright This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997
Associated
Alleles
Symbol Name
Pinx1tm1.1Kplu PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu
Terttm1Leah telomerase reverse transcriptase; targeted mutation 1, Lea Harrington
Associated
Genotypes
Allelic Composition Genetic Background
Pinx1tm1.1Kplu/Pinx1+
Terttm1Leah/Terttm1Leah 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
MGI 6.24 		The Jackson Laboratory