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| Caption | Eye and skeletal phenotype of Alkbh1tm1Klng/Alkbh1tm1Klng embryos and newborns, showing ossified areas in red and cartilage in blue. (A) Side view of wild-type and Alkbh1tm1Klng/Alkbh1tm1Klng(Alkbh1-/-) embryos at E18.5. The mutant has a bilateral anophthalmic phenotype, a shortened snout and slightly reduced body size. (B) Skeletal staining of E18.5 embryos displaying missing nasal bones, shortened frontal bones and upward curving of the lower jaws in mutant. (C) Dorsal view of the craniofacial skeleton of E18.5 embryos showing reduced ossification of the interparietal, parietal and frontal bones leading to bigger sutures in the skull of the mutant. (D) Side view of newborn mice. The mutant has a unilateral microphthalmic eye phenotype and reduced body size. (E) Skeletal staining of the rib cage and sternum (in magnification) revealing delayed ossification and severe aberrant fusion of the sternal bands in mutant newborn mice. Interparietal, ip; parietal, p; frontal, f; nasal, n. (F) Dorsal view of the craniofacial skeleton of newborns demonstrating bigger sutures in the skull of mutant mice. | ||||
| Copyright | This image is from Nordstrand LM, PLoS One 2010;5(11):e13827, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:166841 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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