Phenotype Image Detail

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Phenotype Image Detail

Image

Caption

Complementation test confirms that the nmf223 phenotype is due to a mutation in Lama1. Fundus photographs demonstrate a normal fundus in Lama1^nmf223/Lama1⁺ mice (A), whereas Lama1^nmf223/Lama1^tm1.1Olf (Lama^delta/nmf223) mice experience vitreal fibroplasia and vessel tortuosity (B).

This image is from Edwards MM, J Biol Chem 2010 Mar 5;285(10):7697-711 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160722

Associated
Alleles

Symbol	Name
Lama1^nmf223	laminin, alpha 1; neuroscience mutagenesis facility, 223
Lama1^tm1.1Olf	laminin, alpha 1; targeted mutation 1.1, Olivier Lefebvre

Associated
Genotypes

Allelic Composition	Genetic Background
Lama1^nmf223/Lama1^tm1.1Olf	involves: 129S2/SvPas * C57BL/6J

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