About   Help   FAQ
Phenotype Image Detail
Image
Caption Gross morphology and histological abnormalities in Ryr1tm1.1Dhm/Ryr1tm1.1Dhm neonates. Gross lateral view of wild-type (A) and Ryr1tm1.1Dhm/Ryr1tm1.1Dhm (B) littermates. Note the smaller size, the curved embryonic posture, and the transparent skin of the mutant pup (B). (C-F) HE stained tissue sections. (C and D) Sections through the skin layers at the cervical region. Arrow shows the dermis. BF, brown fat; SM, skeletal muscle. Magnification x20. (E and F) Sections of hind limb skeletal muscle. Magnification x20. (G and H) Electron micrographs of myotubes from E18 fetal diaphragm. Arrowheads show myofibril branchings in mutant myotubes (H). Triads, indicated with arrows, are more frequent in wild-type muscles (G).
Copyright This image is from Zvaritch E, Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18537-42. Copyright 2007 National Academy of Sciences, U.S.A. J:127629
Associated
Alleles
Symbol Name
Ryr1tm1.1Dhm ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan
Associated
Genotypes
Allelic Composition Genetic Background
Ryr1tm1.1Dhm/Ryr1tm1.1Dhm involves: 129S6/SvEvTac * 129X1/SvJ
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory