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| Caption | (A) Loss of hind limb extension reflex in Ltn1lister/Ltn1lister mice manifested by hind limb clenching when lifted by the tail. (B) Motor function of homozygous mutants (white bars, n=8) compared with Ltn1lister/Ltn1+ (gray bars, n=12) and wild-type littermates (black bars, n=12) measured by accelerated rotarod test. Wild-type versus homozygous mutant mice: P < 0.0005 at 3 weeks of age, P < 0.02 at 6 weeks of age, P < 0.0005 at 9 weeks of age. Heterozygous (n=12) versus wild-type mice (n=10): P=0.127 at 63 weeks of age. (C) Survival curve of homozygous mutants (white circles, n=25) compared with heterozygous and wild-type littermates (black circles, n=25). (D) Body weight curve for wild-type (black circles, n=14), heterozygotes (gray circles, n=32) and homozygous mutant mice (white circles, n=14). | ||||
| Copyright | This image is from Chu J, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2097-103. Copyright 2009 National Academy of Sciences, U.S.A. J:146493 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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