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| Caption | Increased apoptosis associated with disrupted polarity complexes in developing kidney of Lin7ctm2Dsb/Lin7ctm2Dsb Tg(Pax3-cre)1Joe mice. A: Apoptotic cells were visualized in embryonic kidneys (E14.5) with Lysotracker (red). Cytokeratin (green) and DAPI (blue) label epithelia and nuclei, respectively. As compared with control littermates, Lin7ctm2Dsb/Lin7ctm2Dsb Tg(Pax3-cre)1Joe (MMKO) kidneys showed a dramatic increase in the number of apoptotic cells. Bars = 100um. B: Kidney homogenates from Lin7ctm2Dsb/Lin7ctm2Dsb and Lin7ctm2Dsb/Lin7ctm2Dsb Tg(Pax3-cre)1Joe mice immunoblotted for proteins of the CRB-3 and DLG polarity complexes show reduced expression of both complexes in Lin7ctm2Dsb/Lin7ctm2Dsb Tg(Pax3-cre)1Joe kidneys. | ||||||
| Copyright | This image is from Olsen O, J Cell Biol 2007 Oct 8;179(1):151-64, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:134806 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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