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| Caption | A: Dissected urinary tracts from P0 pups show significantly smaller kidneys in Lin7ctm1Dsb/Lin7ctm1Dsb (-/-) mice as compared with Lin7ctm1Dsb/Lin7c+ (+/-)littermates. A, adrenal gland; B, bladder; K, kidney; T, testis; U, ureter. B: Kidneys from adult mutant mice are hypoplasic, dysplasic and cystic; arrows mark cysts. E: Hematoxylin and eosin stained kidney section from a 6 week old heterozygous mouse shows normal arrangement of densely packed tubules (left). Kidney from a homozygous mutant littermate shows marked tubulointerstitive changes, including dilation of tubular lumina, tubular dedifferentiation, and fibrosis (right). Asterisks mark tubules with epithelia undergoing dedifferentiation, and arrows show dedifferentiated tubules. F: Trichrome stained kidney section from 6 week old heterozygous mouse displays little or no collagen deposition (left). In contrast, a kidney from a homozygous mutant littermate stains bright blue (arrows), revealing extensive fibrosis (right). | ||||
| Copyright | This image is from Olsen O, J Cell Biol 2007 Oct 8;179(1):151-64, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:134806 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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