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| Caption | A: Morphological analysis of Chmp5tm1Gho/Chmp5tm1Gho embryos. Lateral view of wild-type (+/+) embryos and mutant (-/-) littermates at E7.5, E7.75, E8.5, and E9.25. B: Lateral, front and ventral view of E8.75 mutant embryos. The yolk sac was removed from the embryos. Al, allantois; Am, anmion; Hf, head fold; M, midline. C: Histological analysis of E8.5 mutant embryos. Ht, heart; S, somite. D: Abnormal heart formation in mutant embryos revealed by whole-mount in situ hybridization with the cardiac marker Nkx2.5. (top) Arrows and arrowhead indicate heart tissue. Masive cell death in mutant embryos revealed by TUNEL staining of E8.5 embryos. (bottom) Arrow indicates apoptotic cells. Bars: C, 50 um; D, 100 um. | ||||
| Copyright | This image is from Shim JH, J Cell Biol 2006 Mar 27;172(7):1045-56, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:107913 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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