Phenotype Image Detail

Image

Caption

Skeletal phenotype of Col1a1^tm1.1Jcm/Col1a1⁺ (Brt1IV, center panel) and Col1a1^tm1Jcm/Col1a1⁺ (Brt1II, right panel) mice. Skeletal staining confirmed the characteristic severe osteogenesis imperfecta (OI) phenotype in Col1a1^tm1.1Jcm/Col1a1⁺ mice, including long bone (arrowheads) and rib fractures (arrows), poor skeletal mineralization, flared ribcage, shorter vertebral bodies, kyphosis and narrow pelvis. Skeletal staining of the Col1a1^tm1Jcm/Col1a1⁺ mice (Brt1II, right panel) shows rib fractures (arrows), poor skeletal mineralization, and shorter vertebral bodies. For the skeletal staining Alizarin Red, specific for bone, and Alcian Blue, specific for cartilage, were used.

This image is from Forlino A, J Biol Chem 1999 Dec 31;274(53):37923-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:59168

Associated
Alleles

Symbol	Name
Col1a1^tm1.1Jcm	collagen, type I, alpha 1; targeted mutation 1.1, Joan C Marini
Col1a1^tm1Jcm	collagen, type I, alpha 1; targeted mutation 1, Joan C Marini

Associated
Genotypes

Allelic Composition	Genetic Background
Col1a1^tm1Jcm/Col1a1⁺	either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)
Col1a1^tm1.1Jcm/Col1a1⁺	either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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