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| Caption | (a) Inflammatory foci were scattered in the liver of a 2-month-old Gba1tm1Rlp/Gba1tm1Rlp mouse (arrows). (b) Higher magnification of an inflammatory area. Note the apoptotic hepatocyte in the inflammatory area (arrow). (c) Immunostaining with F4/80 antibody to visualize ramified Kupffer cells in wild-type liver sections. (d) In mutant liver, the F4/80-positive Kupffer cells were amoeboid and swollen. (e) TUNEL-positive, apoptotic nuclei (arrows) were distinguished in the inflammatory lesion of the mutant mouse. (f) TNF-alpha mRNA expression in the liver of mutant and wild type mice. *P <0.001. Results are means +/- SEM for four to seven mice each. Scale bars: 50um. | ||||
| Copyright | This image is from Mizukami H, J Clin Invest 2002 May;109(9):1215-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76409 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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