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| Caption | A: Ccnb1ip1mei4/Ccnb1ip1+ seminiferous tubule cross sections stained with hematoxylin and eosin show normal telophase and metaphase I structures (black arrowheads, respectively) as well as postmeiotic round spermatids and elongating differentiating spermatids (white arrows). B: Ccnb1ip1mei4/Ccnb1ip1mei4 sections show abnormal metaphase and anaphase I-like spermatocytes with disrupted chromosome congression to the metaphase plate and aberrant chromosome distribution on the spindle (black arrows). C & D: Homozygous mutant seminiferous tubules have significantly greater numbers of apoptotic cells (brown cell, black arrow) then wild type tubules (D versus C, respectively). E & F: The ovaries of homozygous mutant females appear histologically normal. Hematoxylin and eosin stained cross sections reveal follicles and oocytes in all stages of development in normal (E) and mutant mice (F). G & H: Hoechst-stained metaphase I chromosome structures occur normally in heterozygous oocytes (white arrows, G) and abnormally (asterisks, H) in homozygous oocytes. Infrequently, normal metaphase chromosomes structures are seen in mutant oocytes (white arrow, [H]). Spindles in (G & H) are labeled with anti-b-tubulin antibody. | ||||
| Copyright | This image is from Ward JO, PLoS Genet 2007 Aug 31;3(8):e139, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:125220 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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