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| Caption | A-I: Hematoxylin/eosin stained adult brain. Agenesis of the corpus callosum (CC) observed in an adult Msi1tm1Okn/Msi1tm1Okn mouse (B, arrowheads) compared with the normal CC in a wild type littermate (A). C & D: Higher magnifications view of the normal CC and the Probst's bundle, respectively. E-I: Hydrocephalus of the adult mutant mouse. (E & F) Sagittal sections. (G-I) Coronal sections at the level of the anterior commissure. (F & I) A severe hydrocephalic mutant showing massive ventricular dilation. (H) Moderate dilation of the lateral ventricles accompanied by cavitation of the septum pellucidum and hypoplasia of the septum. J-L: Coronal sections through the aqueduct of the P7 brain, showing abnormal accumulation and polyposis of ependymal cells surrounding the Sylvius aqueduct and subcommissural organ (SCO). (M & M') mRNA in situ hybridization analysis of msi1 and msi2 in the wild type E12.5 telecephalon showing their expression in the ventricular zone (VZ). (N & N') Immunohistochemical detection of Msi1 and Msi2 in ependymal cells surrounding the aqueduct of wild type P3 mice. Immunoactivities were visualized by DAB (brown) and the nuclei were counterstained with hematoxylin (O & O') Expression of Msi2 in the subventricular zone (SVZ) and ependymal cells lining the lateral centricle of a hydrocephalic muatnt mouse (O') and a wild type littermate (O) at P3. The mutant mouse tissue shows partial destruction of the SVZ (arrow). Abbreviations: lv, lateral ventricle; aq, Sylvius aqueduct; *, septum pellucidum Scale bars: A & B. 150um; C,D & J-L, 50um; E-I, 1mm; M, 30um; N, 10um; O, 100um | ||||
| Copyright | This image is from Sakakibara S, Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15194-9. Copyright 2002 National Academy of Sciences, U.S.A. J:81794 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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