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| Caption | Lateral view of the wild-type (A) and Mapk7tm1Kda/Mapk7tm1Kda (B) E9.5 embryos demonstrate retarded cardiac development in homozygous mutant embryos. Arrows point to the heart region. Histological examination of wild type (C) and mutant mouse (D) hearts revealed that mutant mouse hearts failed to undergo normal looping. The common atrial chamber of the mutant hearts also appeared enlarged, the ventricular trabeculations (arrowheads) were attenuated and disorganized, and there was notable pericardial edema (asterisk). High-power magnification of the hearts of wild-type (E) and mutant (F) embryos revealed that the endothelial cells (arrowheads) of mutant hearts were rounded as compared with the thin, elongated cells present in the wild type. Abbreviations: atrium (A); ventricle (V). | ||||
| Copyright | This image is from Regan CP, Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9248-53. Copyright 2002 National Academy of Sciences, U.S.A. J:77725 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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