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| Caption | A-E: Selected serial transverse sections, from cephalad to caudad, of a Myh10tm2Rsad/Myh10tm2Rsad mouse heart. F: Transverse section of a wild type mouse heart at approximately the same level as C. G & H: Sagittal sections of another homozygous mutant mouse heart. I: Sagittal section of a wild type mouse heart. (Hematoxylin and eosin stained). (A) Cross-sectional view of the aorta and the pulmonary artery at the levels of the semilunar valves, showing the positions of the two vessels, and the uppermost portion of the lateral wall of the left ventricle (LV). AV, aortic valve; PV, pulmonary valve. (B) This section shows the uppermost portion of the ventricular septal defect (VSD). The mitral valve (MV) is also shown. Comparison with A shows that the VSD is located beneath the aortic valve. (C) Shown are the VSD, the MV, the tricuspid valve (TV), and the right ventricular outflow tract (RV), which is narrowed by hypertrophic muscle (*). (D) The edge of the membranous portion of the ventricular septum (VS), the MV, and the TV are demonstrated. (E) The left and right ventricular walls and cavities are evident, as is the muscular portion of the VS. (F) Transverse section of wild type mouse heart. (G) Sagittal sections of a homozygous mutant heart showing the VSD and the rightward malposition of the AV. (H) View showing the relationships of the AV to the left ventricular outflow tract in the area adjacent to the VS. (I) Sagittal section of wild type mouse heart showing the normal relationships of the VS to the AV and aorta (A). | ||||
| Copyright | This image is from Tullio AN, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12407-12. Copyright 1997 National Academy of Sciences, U.S.A. J:44181 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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