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Phenotype Image Detail
Caption A: X-ray image of a 5 week old wild-type (left) and Smpd3tm1Wst/Smpd3tm1Wst (right) littermates. The long bones of the homozygous mouse are proportionally shorter, and the bone structure is more translucent. Arrows, multiple deformations of femur, tibia and fibula. B: Cortices of tibia shafts of male wild-type and homozygous mice at 6 weeks of age. The red bar points to the different thickness of cortices. C & D: Proximal tibia of wild-type (C) and homozygous mutant (D) mice sections. Abbreviations: growth plate (gp); hypertrophic zone (hz); secondary ossification center (oc); vascular buds (vb) Magnification: x40 Scalebar: 7um
Copyright This image is from Stoffel W, Proc Natl Acad Sci U S A 2005 Mar 22;102(12):4554-9. Copyright 2005 National Academy of Sciences, U.S.A. J:97284
Symbol Name
Smpd3tm1Wst sphingomyelin phosphodiesterase 3, neutral; targeted mutation 1, Wilhelm Stoffel
Allelic Composition Genetic Background
Smpd3tm1Wst/Smpd3tm1Wst involves: 129S1/Sv

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory