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| Caption | A & B: Compared to the wild-type pup (A), the Tcof1tm1Mjd/Tcof+ pup exhibits a shortened and domed-shaped head with frontonasal dysplasia (arrow). C-J: Skeletal staining of E17.5 wild-type (C,E,G & I) and heterozygous mutant embryos (D,F,H & J) reveals hypoplasia of numerous craniofacial bones including the nasal, frontal, premaxillary, maxillary, mandibular and temporal bones together with cleft palate (arrow) in mutant embryos. K & L: Comparison of wild-type (K) and heterozygous mutant (L) embryo skeletal preparations, cranioskeletal hypoplasia is evident at E15.5 in the frontal, premaxillary, and maxillary elements. M & N: Transverse histological sections of E14.5 wild-type (M) and heterozygous mutant (N) embryos highlight the absence of complete midline fusion (arrowhead) and the lack of a nasal septum and conchae in the heterozygous mutant mouse embryos. Abbreviations: nasal (n); frontal (f); premaxillary (pmx); maxillary (mx); mandibular (md) temporal bone (t) nasal septum (ns); conchae (c) | ||||
| Copyright | This image is from Dixon J, Proc Natl Acad Sci U S A 2006 Sep 5;103(36):13403-8. Copyright 2006 National Academy of Sciences, U.S.A. J:112900 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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