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| Caption | Plastic sections (1um) of eyes from wild type and Pax6Sey/Pax6+ mice at E13.5 (A & B) and E16.5 (C-F). A: Extensive vacuolation of the heterozygous mutant eye lens is seen, with persistence of a lens-corneal plug (arrowhead). B: A wild type littermate. C-F: Lens-corneal plug, an adhesion between the corneal epithelium and the lens epithelium (arrowhead) persists at E16.5. D: A wild-type E16.5 eye. E: Multiple adhesions between the lens and corneal endothelium in the E16.5 heterozygous mouse eye with reduction of the anterior chamber. G: BrdUrd staining (brown) in E12.5 lens shows no defects in the pattern of proliferation of the heterozygous mutant mouse eyes. H: Flourescence TUNEL in the E12.5 heterozygous mouse lens shows apoptotic cells only in the lens-corneal bridge. Apoptotic cells were not found in the lens epithelium of E12.5 wild type littermates eyes. Abbreviations: cornea (c); neural retina (ne) corneal epithelium (ce); lens epithelium (le) Scalebar: 50um | ||||
| Copyright | This image is from Collinson JM, Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9688-93. Copyright 2001 National Academy of Sciences, U.S.A. J:71087 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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