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| Caption | A: A phenotypically altered renal tubule (arrow) shown by HE staining. B: Macroscopic renal cysts (arrows) developed by a 15 month old Tsc1tm1Hin/Tsc1+ mouse. C & D: Histology of a renal cystadenoma shown by HE staining. D is an enlarged view of region enclosed with a rectangle in C. E: Histology of a renal adenoma exhibiting tubular structure shown by HE staining. F: Loss of wild-type Tsc1 allele in a renal tumor of Tsc1tm1Hin/Tsc1+ mice. Representative result of LOH analysis is shown. Lanes T, tumor; N, normal counterpart; , no input DNA sample. Products from mutant allele (M, 220 bp) and from wild-type allele (W, 192 bp) are indicated. G: Macroscopic renal cysts (arrows) developed in an 11 week old heterozygous mutant mouse transplacentally treated with ENU. H: Histology of renal cystodenoma developed by ENU treatment shown by HE stainging. | ||||
| Copyright | This image is from Kobayashi T, Proc Natl Acad Sci U S A 2001 Jul 17;98(15):8762-7. Copyright 2001 National Academy of Sciences, U.S.A. J:70463 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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